We all can view the following videocast tomorrow
"The Lipid and the Virus: The Story of Cholesterol and HIV" - a lecture by Dr. James Hildreth on September 30, 2009
HIV-1 replication involves a series of highly orchestrated steps that involve numerous host cell proteins. Our work has shown that HIV incorporates many host proteins that retain their function including cell adhesion molecules. In studying the mechanism of host cell protein acquisition by HIV we discovered that membrane microdomains highly enriched in cholesterol serve as budding sites for the virus. This observation led us to evaluate the role of cholesterol in HIV biology. Our work and that of others has demonstrated that cholesterol is involved in virus entry as well as assembly and release.
Our recent work has shown that proteins involved in cholesterol homoeostasis and trafficking participate in virus replication. Further, we have shown that cholesterol homeostasis may regulate transcription of the HIV LTR. These recent observations have important implications for virus pathogenesis, health disparities of AIDS, and development of new anti-HIV interventions.
The Wednesday Afternoon Lecture Series Presents:
"The Lipid and the Virus: The Story of Cholesterol and HIV"
James Hildreth, M.D., Ph.D.
Director of the Center for AIDS Health Disparities Research,
Associate Director of the Vanderbilt-Meharry Center for AIDS Research,
Program Director for the Research Centers in Minority Institutions, and
Professor of Internal Medicine at the Meharry Medical College in Nashville,
Wednesday, September 30, 2009
3 - 4 p.m.
Building 10, Masur Auditorium
NIH Main Campus
To view the lecture abstract, view the videocast and more, visit